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Inside Cover: Synergistic Effects of Metals in a Promising Ru II −Pt II Assembly for a Combined Anticancer Approach: Theoretical Exploration of the Photophysical Properties (Chem. Eur. J. 27/2016)
Author(s) -
Alberto Marta E.,
Russo Nino,
Adamo Carlo
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602147
Subject(s) - chromophore , chemistry , moiety , ruthenium , ligand (biochemistry) , photochemistry , singlet oxygen , molecule , stereochemistry , oxygen , catalysis , organic chemistry , biochemistry , receptor
United against cancer : Ru II −Pt II complexes are a class of bioactive molecules that are of interest as anticancer agents. They are obtained by combining a light‐absorber chromophore with a cisplatin‐like unit. The Pt II moiety tunes the photophysical properties of the Ru II chromophore, ensuring efficient singlet oxygen generation and enhancing the potential efficiency of the conjugate in photodynamic therapy, whereas the Ru II chromophore promotes an alternative activation mechanism of the Pt II ligand before reaching the biological target, through low‐energy light‐induced photolabilization of the Pt−Cl bond promoted, upon irradiation, by a triplet metal‐to‐ligand charge transfer state. More information can be found in the Full Paper by M. E. Alberto et al. on page 9162 ff.