Premium
Self‐Immolative Linkers as Caps for the Design of Gated Silica Mesoporous Supports
Author(s) -
Juárez L. Alberto,
Añón Elena,
Giménez Cristina,
Sancenón Félix,
MartínezMáñez Ramón,
Costero Ana M.,
Gaviña Pablo,
Parra Margarita,
Bernardos Andrea
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602126
Subject(s) - sulforhodamine b , mesoporous silica , moiety , chemistry , deprotonation , molecule , mesoporous material , phenol , nanoparticle , chemical engineering , nanotechnology , organic chemistry , materials science , catalysis , ion , biochemistry , cytotoxicity , engineering , in vitro
A new hybrid material based on sulforhodamine B dye‐loaded silica mesoporous nanoparticles capped with a self‐immolative gate has been synthesized and characterized. The gated material's controlled release behavior is monitored under different pH conditions. Under acidic and neutral conditions, a low level of dye release is detected. However, at slightly basic pH, significant dye release occurs owing to deprotonation of the phenol moiety in the capping molecule, which results in its disassembly.