Premium
Rhodium(I)‐Catalyzed Benzannulation of Heteroaryl Propargylic Esters: Synthesis of Indoles and Related Heterocycles
Author(s) -
Li Xiaoxun,
Xie Haibo,
Fu Xiaoning,
Liu Jitian,
Wang Haoyuan,
Xi Baomin,
Liu Peng,
Xu Xiufang,
Tang Weiping
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602088
Subject(s) - rhodium , catalysis , chemistry , benzene , ring (chemistry) , combinatorial chemistry , organic chemistry
A de novo synthesis of a benzene ring allows for the preparation of a diverse range of heterocycles including indoles, benzofurans, benzothiophenes, carbazoles, and dibenzofurans from simple heteroaryl propargylic esters using a unified carbonylative benzannulation strategy. Multiple substituents can be easily introduced to the C4–C7 positions of indoles and related heterocycles.