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Back Cover: Synthetically Tuning the 2‐Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways (Chem. Eur. J. 27/2016)
Author(s) -
Basak Akash,
Abouelhassan Yasmeen,
Norwood Verrill M.,
Bai Fang,
Nguyen Minh Thu,
Jin Shouguang,
Huigens Robert W.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201602069
Subject(s) - enterococcus faecium , quinoline , amination , staphylococcus epidermidis , biofilm , alkylation , reductive amination , chemistry , combinatorial chemistry , microbiology and biotechnology , staphylococcus aureus , antibiotics , biology , biochemistry , catalysis , organic chemistry , bacteria , genetics
The 2‐position of the halogenated quinoline (HQ) scaffold can be dramatically tuned through diverse and practical synthetic pathways, including reductive amination and alkylation reactions. New HQs discovered during these investigations potently eradicate methicillin‐resistant Staphylococcus aureus (MRSA), methicillin‐resistant Staphylococcus epidermidis (MRSE) and vancomycin‐resistant Enterococcus faecium (VRE) biofilms, which display high levels of tolerance towards conventional antibiotic therapies. The background image is reproduced with permission and copyright of the British Editorial Society of Bone and Joint Surgery ( Bone Joint J . 2013 , 95B , 678–682; Figure 2 b). More information can be found in the Full Paper by R. W. Huigens III et al. on page 9181 ff.