Premium
Self‐Assembly of Proteins: Towards Supramolecular Materials
Author(s) -
Yang Liulin,
Liu Aijie,
Cao Shuqin,
Putri Rindia M.,
Jonkheijm Pascal,
Cornelissen Jeroen J. L. M.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201601943
Subject(s) - supramolecular chemistry , nanotechnology , scaffold protein , self assembly , scaffold , protein design , synthetic biology , computational biology , fusion protein , chemistry , computer science , protein structure , biology , materials science , biochemistry , signal transduction , crystallography , recombinant dna , database , gene , crystal structure
The study of protein self‐assembly has attracted great interest over the decades, due to the important role that proteins play in life. In contrast to the major achievements that have been made in the fields of DNA origami, RNA, and synthetic peptides, methods for the design of self‐assembling proteins have progressed more slowly. This Concept article provides a brief overview of studies on native protein and artificial scaffold assemblies and highlights advances in designing self‐assembling proteins. The discussions are focused on design strategies for self‐assembling proteins, including protein fusion, chemical conjugation, supramolecular, and computational‐aided de novo design.