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Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes
Author(s) -
Wieczorek Anna,
Błauż Andrzej,
Żal Aleksandra,
Arabshahi Homayon John,
Reynisson Jóhannes,
Hartinger Christian G.,
Rychlik Błażej,
Plażuk Damian
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201601809
Subject(s) - paclitaxel , moiety , docetaxel , taxane , tubulin , chemistry , microtubule , mode of action , stereochemistry , epothilone , pharmacology , biochemistry , biology , chemotherapy , medicine , cancer , breast cancer , microbiology and biotechnology
A series of ferrocenyl analogues and derivatives of paclitaxel and docetaxel were synthesised and assayed for their antiproliferative/cytotoxic effects, impact on the cell cycle distribution and ability to induce tubulin polymerisation. The replacement of the 3′‐ N ‐benzoyl group of paclitaxel with a ferrocenoyl moiety, in particular, led to formation of an analogue that was at least one order of magnitude more potent in terms of antiproliferative activity than the parent compound (IC 50 values of 0.11 versus 1.11 μ m , respectively), but still preserved the classical taxane mode of action, that is, microtubule stabilisation leading to mitotic arrest. Molecular docking studies revealed an unexpected binding pocket in the tubulin structure for the ferrocenoyl group introduced in the paclitaxel backbone.