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Synthesis of 1,2,4‐Triazolo[4,3‐ a ]pyridines and Related Heterocycles by Sequential Condensation and Iodine‐Mediated Oxidative Cyclization
Author(s) -
Li Ertong,
Hu Zhiyuan,
Song Lina,
Yu Wenquan,
Chang Junbiao
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201601744
Subject(s) - iodine , chemistry , condensation , oxidative phosphorylation , aryl , combinatorial chemistry , organic chemistry , biochemistry , physics , alkyl , thermodynamics
A facile and efficient approach to access 1,2,4‐triazolo[4,3‐ a ]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine‐mediated oxidative cyclization. This transition‐metal‐free synthetic process is broadly applicable to a variety of aromatic, aliphatic, and α,β‐unsaturated aldehydes, and can be conveniently conducted on the gram scale.