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Biodegradable Oxamide‐Phenylene‐Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells
Author(s) -
Croissant Jonas G.,
Fatieiev Yevhen,
Julfakyan Khachatur,
Lu Jie,
Emwas AbdulHamid,
Anjum Dalaver H.,
Omar Haneen,
Tamanoi Fuyuhiko,
Zink Jeffrey I.,
Khashab Niveen M.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201601714
Subject(s) - mesoporous organosilica , nanoparticle , drug delivery , mesoporous silica , mesoporous material , materials science , oxamide , biocompatible material , nanotechnology , nanocomposite , chemical engineering , chemistry , organic chemistry , polymer chemistry , catalysis , biomedical engineering , medicine , engineering
We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene‐based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.