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Cover Picture: Synthesis of ( E )‐4‐Bromo‐3‐methoxybut‐3‐en‐2‐one, the Key Fragment in the Polyhydroxylated Chain Common to Oscillariolide and Phormidolides A–C (Chem. Eur. J. 21/2016)
Author(s) -
Gil Alejandro,
LamarianoMerketegi Janire,
Lorente Adriana,
Albericio Fernando,
Álvarez Mercedes
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201601577
Subject(s) - moiety , total synthesis , marine invertebrates , stereochemistry , biology , sponge , chemistry , computational biology , ecology , botany
Natural products are extracted from biological organisms like bacteria, fungi, marine invertebrates, plants, or animals. This cover picture shows a typical sequential cycle in which the biology and the chemistry are closely related. Phormidolides and oscillariolides are secondary metabolites isolated from marine organisms. Bromomethoxydiene (BMD) is a synthetically challenging motif common to all the compounds in these families. The first stereoselective synthetic approach to “fish” this complicated domain has been described and this strategy may be applied to the total synthesis of all the compounds that share this BMD moiety. More information can be found in the Communication by M. Álvarez et al. on page 7033 ff.