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Inside Cover: New Chiral Reagent for Installation of Pharmacophoric ( S )‐ or ( R )‐2‐(Alkoxyphosphono)‐1‐amino‐2,2‐difluoroethyl Groups (Chem. Eur. J. 21/2016)
Author(s) -
Xie Chen,
Zhang Lijun,
Mei Haibo,
Pajkert Romana,
Ponomarenko Maksym,
Pan Yi,
Röschenthaler GerdVolker,
Soloshonok Vadim A.,
Han Jianlin
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201601402
Subject(s) - reagent , chemistry , indole test , combinatorial chemistry , fluorine , group (periodic table) , organic synthesis , stereochemistry , organic chemistry , catalysis
Asymmetric methods for practical synthesis of fluorine‐containing compounds are in extremely high demand in virtually all branches of the chemical industry. This work introduces a new chiral reagent for generalized installation of pharmacophoric ( S )‐ or ( R )‐2‐(alkoxyphosphono)‐1‐amino‐2,2 difluoroethyl group into organic compounds. The original synthetic application of this new reagent is exemplified by Friedel–Crafts reactions with various indole derivatives, which proceed with excellent stereochemical outcome. More information can be found in the Communication by G.‐V. Röschenthaler, V. A. Soloshonok, J. Han et al. on page 7036 ff.