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New Prospects toward the Synthesis of Difluoromethylated Phosphate Mimics
Author(s) -
Ivanova Maria V.,
Bayle Alexandre,
Besset Tatiana,
Pannecoucke Xavier,
Poisson Thomas
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201601310
Subject(s) - phosphonate , phosphate , molecule , chemistry , combinatorial chemistry , nanotechnology , organic chemistry , materials science
The difluoromethyl phosphonate motif plays a crucial role in the development of bioactive molecules as it is considered as a phosphate bioisoster. Since 2010, a renewal of interest to enlarge the panel of reactions to access these difluoromethylated phosphonate‐containing molecules has been witnessed. This Concept article charts the recent progress that has been made.