Rhodium‐Catalyzed Enantioselective Arylation of Aliphatic Imines | Zendy

Kato Naoya | Zendy; Shirai Tomohiko | Zendy; Yamamoto Yasunori | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Rhodium‐Catalyzed Enantioselective Arylation of Aliphatic Imines

Author(s) -

Kato Naoya,

Shirai Tomohiko,

Yamamoto Yasunori

Publication year - 2016

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201601246

Subject(s) - rhodium , enantioselective synthesis , catalysis , aldimine , chemistry , phosphoramidite , organic chemistry , combinatorial chemistry , dna , biochemistry , oligonucleotide

Chiral rhodium(I)‐catalyzed highly enantioselective arylation of aliphatic N ‐sulfonyl aldimines with arylboronic acids has been developed. This transformation is achieved by the use of a rhodium/bis(phosphoramidite) catalyst to give enantiomerically enriched α‐branched amines (up to 99 % ee ). In addition, this system enables efficient synthesis of (+)‐NPS R‐568 and Cinacalcet which are calcimimetic agents.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research