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Rhodium‐Catalyzed Enantioselective Arylation of Aliphatic Imines
Author(s) -
Kato Naoya,
Shirai Tomohiko,
Yamamoto Yasunori
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201601246
Subject(s) - rhodium , enantioselective synthesis , catalysis , aldimine , chemistry , phosphoramidite , organic chemistry , combinatorial chemistry , dna , biochemistry , oligonucleotide
Chiral rhodium(I)‐catalyzed highly enantioselective arylation of aliphatic N ‐sulfonyl aldimines with arylboronic acids has been developed. This transformation is achieved by the use of a rhodium/bis(phosphoramidite) catalyst to give enantiomerically enriched α‐branched amines (up to 99 % ee ). In addition, this system enables efficient synthesis of (+)‐NPS R‐568 and Cinacalcet which are calcimimetic agents.