Premium
Modular Synthesis of Novel Macrocycles Bearing α,β‐Unsaturated Chemotypes through a Series of One‐Pot, Sequential Protocols
Author(s) -
Javed Salim,
Bodugam Mahipal,
Torres Jessica,
Ganguly Arghya,
Hanson Paul R.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201601004
Subject(s) - chemotype , modular design , series (stratigraphy) , sulfur , bearing (navigation) , combinatorial chemistry , phosphorus , chemistry , computer science , organic chemistry , biology , programming language , artificial intelligence , chromatography , paleontology , essential oil
A series of one‐pot, sequential protocols was developed for the synthesis of novel macrocycles bearing α,β‐unsaturated chemotypes. The method highlights a phosphate tether‐mediated approach to establish asymmetry, and consecutive one‐pot, sequential processes to access the macrocycles with minimal purification procedures. This library amenable strategy provided diverse macrocycles containing α,β‐unsaturated carbon‐, sulfur‐, or phosphorus‐based warheads.