Premium
Gadolinium‐Decorated Silica Microspheres as Redox‐Responsive MRI Probes for Applications in Cell Therapy Follow‐Up
Author(s) -
Muñoz Úbeda Monica,
Carniato Fabio,
Catanzaro Valeria,
Padovan Sergio,
Grange Cristina,
Porta Stefano,
Carrera Carla,
Tei Lorenzo,
Digilio Giuseppe
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600962
Subject(s) - gadolinium , redox , biocompatible material , microsphere , chelation , chemistry , materials science , magnetic resonance imaging , cell , biophysics , biomedical engineering , nanotechnology , chemical engineering , medicine , biochemistry , inorganic chemistry , radiology , organic chemistry , biology , engineering
The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox‐responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd‐chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.