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Fluorescent H‐Aggregates Hosted by a Charged Cyclodextrin Cavity
Author(s) -
Mudliar Niyati H.,
Singh Prabhat K.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600925
Subject(s) - fluorescence , cyclodextrin , thioflavin , chemistry , molecule , amyloid (mycology) , derivative (finance) , organic dye , photochemistry , polymer chemistry , chemical engineering , organic chemistry , inorganic chemistry , medicine , physics , disease , pathology , quantum mechanics , financial economics , engineering , economics , alzheimer's disease
Most macrocyclic host molecules, including cyclodextrins, usually prevent self‐aggregation of the guest organic molecules, by exploiting inclusion complexation of the guest with the host. In this work, it was found that a negatively charged β‐cylcodextrin derivative induces aggregation of a well‐known amyloid sensing dye, Thioflavin‐T, and leads to an unprecedented formation of the rarely observed emissive H‐type aggregates of the dye.