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Supramolecular Antibiotic Switches: A Potential Strategy for Combating Drug Resistance
Author(s) -
Bai Haotian,
Lv Fengting,
Liu Libing,
Wang Shu
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600877
Subject(s) - antibiotics , antibiotic resistance , antimicrobial , infectious disease (medical specialty) , pathogen , drug resistance , drug , intensive care medicine , medicine , biology , risk analysis (engineering) , disease , microbiology and biotechnology , pharmacology , pathology
Bacterial infectious disease is a serious public health concern throughout the world. Pathogen drug resistance, arising from both rational use and abuse/misuse of germicides, complicates the situation. Aside from developing novel antibiotics and antimicrobial agents, molecular approaches have become another significant method to overcome the problem of pathogen drug resistance. Established supramolecular systems, the antibiotic properties of which can be switched “on” and “off” through host–guest interactions, show great potential in combating issues regarding antibiotic resistance in the long term, as indicated by several recent studies. In this Concept, recently developed strategies for antibacterial regulation are summarized and further directions for research into antibiotic switches are proposed.