Catalyst‐Free Three‐Component Tandem CDC Cyclization: Convenient Access to Isoindolinones from Aromatic Acid, Amides, and DMSO by a Pummerer‐Type Rearrangement | Zendy

Wang PengMin | Zendy; Pu Fan | Zendy; Liu KeYan | Zendy; Li ChaoJun | Zendy; Liu ZhongWen | Zendy; Shi XianYing | Zendy; Fan Juan | Zendy; Yang MingYu | Zendy; Wei JunFa | Zendy

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Catalyst‐Free Three‐Component Tandem CDC Cyclization: Convenient Access to Isoindolinones from Aromatic Acid, Amides, and DMSO by a Pummerer‐Type Rearrangement

Author(s) -

Wang PengMin,

Pu Fan,

Liu KeYan,

Li ChaoJun,

Liu ZhongWen,

Shi XianYing,

Fan Juan,

Yang MingYu,

Wei JunFa

Publication year - 2016

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201600865

Subject(s) - tandem , chemistry , component (thermodynamics) , pummerer rearrangement , catalysis , combinatorial chemistry , organic chemistry , materials science , physics , acetic anhydride , thermodynamics , composite material

A catalyst‐free multicomponent CDC reaction is rarely reported, especially for the intermolecular tandem CDC cyclization, which represents an important strategy for constructing cyclic compounds. Herein, a three‐component tandem CDC cyclization by a Pummerer‐type rearrangement to afford biologically relevant isoindolinones from aromatic acids, amides, and DMSO, is described. This intermolecular tandem reaction undergoes a C(sp 2 )−H/C(sp 3 )−H cross‐dehydrogenative coupling, C−N bond formation, and intramolecular amidation. A notable feature of this novel protocol is avoiding a catalyst and additive (apart from oxidant).

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