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A Self‐Assembled Metallomacrocycle Singlet Oxygen Sensitizer for Photodynamic Therapy
Author(s) -
Walker Michael G.,
Jarman Paul J.,
Gill Martin R.,
Tian Xiaohe,
Ahmad Haslina,
Reddy Pattubala A. N.,
McKenzie Luke,
Weinstein Julia A.,
Meijer Anthony J. H. M.,
Battaglia Giuseppe,
Smythe Carl G. W.,
Thomas Jim A.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600852
Subject(s) - singlet oxygen , photodynamic therapy , photochemistry , chemistry , oxygen , organic chemistry
Although metal‐ion‐directed self‐assembly has been widely used to construct a vast number of macrocycles and cages, it is only recently that the biological properties of these systems have begun to be explored. However, up until now, none of these studies have involved intrinsically photoexcitable self‐assembled structures. Herein we report the first metallomacrocycle that functions as an intracellular singlet oxygen sensitizer. Not only does this Ru 2 Re 2 system possess potent photocytotoxicity at light fluences below those used for current medically employed systems, it offers an entirely new paradigm for the construction of sensitizers for photodynamic therapy.