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New Chiral Reagent for Installation of Pharmacophoric ( S )‐ or ( R )‐2‐(Alkoxyphosphono)‐1‐amino‐2,2‐difluoroethyl Groups
Author(s) -
Xie Chen,
Zhang Lijun,
Mei Haibo,
Pajkert Romana,
Ponomarenko Maksym,
Pan Yi,
Röschenthaler GerdVolker,
Soloshonok Vadim A.,
Han Jianlin
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600758
Subject(s) - reagent , chemistry , organic chemistry , combinatorial chemistry , group (periodic table) , friedel–crafts reaction , catalysis
A new chiral reagent has been developed for generalized installation of pharmacophoric ( S )‐ or ( R )‐2‐(alkoxyphosphono)‐1‐amino‐2,2‐difluoroethyl group into organic compounds. The original synthetic application of this new reagent is exemplified by Friedel–Crafts reactions with indoles, which proceed efficiently with excellent diastereoselectivity to give enantiomerically pure products.