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Gd‐TEMDO: Design, Synthesis, and MRI Application
Author(s) -
Boltjes André,
Shrinidhi Annadka,
van de Kolk Kees,
Herdtweck Eberhardt,
Dömling Alexander
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600720
Subject(s) - cyclen , tetrazole , combinatorial chemistry , lanthanide , derivative (finance) , ligand (biochemistry) , chemistry , solid state , stereochemistry , organic chemistry , ion , biochemistry , receptor , financial economics , economics
A simple Ugi tetrazole multicomponent reaction allows the synthesis of a novel macrocyclic cyclen derivative with four appendant tetrazole arms in just two steps in excellent yields. This ligand, called TEMDO, turns out to have a high complexation affinity with lanthanoid metals. Here we describe the design, synthesis, solid‐state structure, binding constant, and some MRI applications of the Gd‐TEMDO complex as the first example of a congeneric family of oligo‐amino tetrazoles.