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Inside Back Cover: Generation of Complex Azabicycles and Carbobicycles from Two Simple Compounds in a Single Operation through a Metal‐Free Six‐Step Domino Reaction (Chem. Eur. J. 15/2016)
Author(s) -
Bock Christina M.,
Parameshwarappa Gangajji,
Bönisch Simon,
Neiss Christian,
Bauer Walter,
Hampel Frank,
Görling Andreas,
Tsogoeva Svetlana B.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600644
Subject(s) - domino , cascade reaction , combinatorial chemistry , cover (algebra) , chemistry , metal , computational chemistry , nanotechnology , materials science , organic chemistry , engineering , catalysis , mechanical engineering
An unprecedented metal‐free two component six‐step domino reaction , which provides a straightforward and atom‐economical route to bioactive azabicycles and carbobicycles, has been developed. The studies were supported by mechanistic investigations of the chemoselective branching step by using DFT methods, accounting for dispersion interactions. This new domino reaction allows the generation, in a single operation, of new artemisinin‐derived hybrid compounds with strong antiviral properties outperforming the clinically used drug ganciclovir. More information can be found in the Full Paper by A. Görling, S. B. Tsogoeva et al. on page 5189 ff.