Premium
Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells
Author(s) -
Croissant Jonas G.,
Fatieiev Yevhen,
Omar Haneen,
Anjum Dalaver H.,
Gurinov Andrey,
Lu Jie,
Tamanoi Fuyuhiko,
Zink Jeffrey I.,
Khashab Niveen M.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600587
Subject(s) - pmos logic , materials science , nanotechnology , nanomaterials , nanoparticle , porosity , phenylene , drug delivery , mesoporous organosilica , mesoporous material , thermal stability , chemical engineering , mesoporous silica , polymer , chemistry , organic chemistry , composite material , transistor , catalysis , engineering , physics , quantum mechanics , voltage
Despite the worldwide interest generated by periodic mesoporous organosilica (PMO) bulk materials, the design of PMO nanomaterials with controlled morphology remains largely unexplored and their properties unknown. In this work, we describe the first study of PMO nanoparticles (NPs) based on meta ‐phenylene bridges, and we conducted a comparative structure–property relationship investigation with para ‐phenylene‐bridged PMO NPs. Our findings indicate that the change of the isomer drastically affects the structure, morphology, size, porosity and thermal stability of PMO materials. We observed a much higher porosity and thermal stability of the para ‐based PMO which was likely due to a higher molecular periodicity. Additionally, the para isomer could generate multipodal NPs at very low stirring speed and upon this discovery we designed a phenylene–ethylene bridged PMO with a controlled Janus morphology. Unprecedentedly high payloads could be obtained from 40 to 110 wt % regardless of the organic bridge of PMOs. Finally, we demonstrate for the first time the co‐delivery of two cargos by PMO NPs. Importantly, the cargo stability in PMOs did not require the capping of the pores, unlike pure silica, and the delivery could be autonomously triggered in cancer cells by acidic pH with nearly 70 % cell killing.