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Back Cover: Indole Synthesis through Sequential Electrophilic N−H and C−H Bond Activation Using Iodine(III) Reactivity (Chem. Eur. J. 13/2016)
Author(s) -
Fra Laura,
Muñiz Kilian
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600558
Subject(s) - indole test , chemistry , reactivity (psychology) , iodine , electrophile , sulfonyl , aniline , medicinal chemistry , stereochemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology , alkyl
The round‐robin of indole cyclization : the eight tentacles of an octopus display the key structures involved in a novel sequential synthesis of indoles. Departing from an aniline bearing a tethered acetylene (lower right), subsequent counterclockwise events include the iodine(III)‐promoted initiation, three charged intermediates throughout the cyclization process and the clipping of the sulfonyl tether to liberate the free indole. More information can be found in the Communication by K. Muñiz and L. Fra on page 4351 ff.