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A General and Selective Rhodium‐Catalyzed Reduction of Amides, N ‐Acyl Amino Esters, and Dipeptides Using Phenylsilane
Author(s) -
Das Shoubhik,
Li Yuehui,
Lu LiangQiu,
Junge Kathrin,
Beller Matthias
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600535
Subject(s) - phenylsilane , rhodium , chemistry , catalysis , medicinal chemistry , stereochemistry , organic chemistry
This article describes a selective reduction of functionalized amides, including N ‐acyl amino esters and dipeptides, to the corresponding amines using simple [Rh(acac)(cod)]. The catalyst shows excellent chemoselectivity in the presence of different sensitive functional moieties.
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