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Brønsted Acid‐Mediated Hydrative Arylation of Unactivated Alkynes
Author(s) -
Kaiser Daniel,
Veiros Luís F.,
Maulide Nuno
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600432
Subject(s) - intermolecular force , aryl , brønsted–lowry acid–base theory , surface modification , chemistry , combinatorial chemistry , solvent , transformation (genetics) , atom (system on chip) , catalysis , organic chemistry , molecule , computer science , alkyl , parallel computing , biochemistry , gene
The Brønsted acid‐mediated reaction of unactivated alkynes with aryl sulfoxides leads to simultaneous hydration and intermolecular C−C bond formation. This solvent‐ and metal‐free transformation directly delivers α‐arylated carbonyl compounds as the products of a formal hydrative arylation in an atom‐economical manner. The products bear useful synthetic handles for further functionalization.