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A Convenient Palladium‐Catalyzed Reductive Carbonylation of Aryl Iodides with Dual Role of Formic Acid
Author(s) -
Qi Xinxin,
Li ChongLiang,
Wu XiaoFeng
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600387
Subject(s) - carbonylation , formic acid , palladium , catalysis , chemistry , aryl , organic chemistry , reductive elimination , halide , combinatorial chemistry , carbon monoxide , alkyl
Palladium‐catalyzed reductive carbonylation of aryl halides represents a straightforward pathway for the synthesis of aromatic aldehydes. The known reductive carbonylation procedures either require CO gas or complexed compounds as CO sources. In this communication, we developed a palladium‐catalyzed reductive carbonylation of aryl iodides with formic acid as the formyl source. As a convenient, practical, and environmental friendly methodology, no additional silane or H 2 was required. A variety of aromatic aldehydes were isolated in moderate to excellent yields under mild reaction conditions. Notably, this is the first procedure on using formic acid as the formyl source.