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Trichloromethylthiolation of N‐Heterocycles: Practical and Completely Regioselective
Author(s) -
Ernst Johannes B.,
Rühling Andreas,
Wibbeling Birgit,
Glorius Frank
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600377
Subject(s) - regioselectivity , reagent , functional group , combinatorial chemistry , chemistry , organic chemistry , catalysis , polymer
The first trichloromethylthiolation of a broad range of indoles and pyrroles is reported employing bench‐stable N ‐trichloromethylthiosaccharin as reagent. This methodology is highly regioselective, exhibits high functional group tolerance, and provides access to two previously unknown classes of potentially bioactive compounds.