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Inside Cover: Activity Enhancement of G‐Quadruplex/Hemin DNAzyme by Flanking d(CCC) (Chem. Eur. J. 12/2016)
Author(s) -
Chang Tianjun,
Gong Hongmei,
Ding Pi,
Liu Xiangjun,
Li Weiguo,
Bing Tao,
Cao Zehui,
Shangguan Dihua
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600251
Subject(s) - hemin , deoxyribozyme , g quadruplex , chemistry , cover (algebra) , biophysics , combinatorial chemistry , biochemistry , dna , heme , enzyme , biology , mechanical engineering , engineering
The flanked sequences containing d(CCC) on the core sequence of parallel G‐quadruplexes improve the binding affinity of hemin to G‐quadruplexes, thereby remarkably enhancing the activity of G‐quadruplex/hemin DNAzyme and the hemin degradation by H 2 O 2 , as well as increasing the tolerance of DNAzyme to pH change. More information can be found in the Full Paper by D. Shangguan et al. on page 4015 ff.