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Photocatalytic/Cu‐Promoted C−H Activations: Visible‐light‐Induced ortho ‐Selective Perfluoroalkylation of Benzamides
Author(s) -
Chen Xiang,
Tan Ze,
Gui Qingwen,
Hu Liang,
Liu Jidan,
Wu Jing,
Wang Guangwei
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600229
Subject(s) - eosin y , photocatalysis , photochemistry , chemistry , visible spectrum , benzoic acid , catalysis , eosin , copper , irradiation , combinatorial chemistry , fluorescence , organic chemistry , materials science , optoelectronics , optics , staining , medicine , physics , pathology , nuclear physics
Abstract A visible‐light‐induced and copper‐promoted perfluoroalkylation of benzamides was successfully developed under the assistance of an 8‐aminoquinoline directing group. It provides a straightforward method for the synthesis of ortho ‐perfluoroalkyl‐substituted benzoic acid derivatives. The reaction employs a cheap organic dye eosin Y as the photoredox catalyst and is run under the irradiation of a 26 W fluorescent LED light bulb.