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Dithioacetal Exchange: A New Reversible Reaction for Dynamic Combinatorial Chemistry
Author(s) -
Orrillo A. Gastón,
Escalante Andrea M.,
Furlan Ricardo L. E.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600208
Subject(s) - disulfide bond , chemistry , intersection (aeronautics) , combinatorial chemistry , computer science , computational chemistry , biochemistry , engineering , aerospace engineering
Reversibility of dithioacetal bond formation is reported under acidic mild conditions. Its utility for dynamic combinatorial chemistry was explored by combining it with orthogonal disulfide exchange. In such a setup, thiols are positioned at the intersection of both chemistries, constituting a connecting node between temporally separated networks.