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Back Cover: Quadruplex DNA‐Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers (Chem. Eur. J. 7/2016)
Author(s) -
Ang Dale L.,
Harper Benjamin W. J.,
Cubo Leticia,
Mendoza Oscar,
Vilar Ramon,
AldrichWright Janice
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600136
Subject(s) - g quadruplex , circular dichroism , terpyridine , dna , platinum , chemistry , stereochemistry , crystallography , biochemistry , catalysis , organic chemistry , metal
G‐quadruplex DNA (QDNA) has been shown to play a role in gene expression, with implications in cell mortality and oncogenesis. Compounds that are capable of preferentially binding to and stabilising QDNA structures are seen as potential novel cancer treatments. The dinuclear platinum complex, pictured, exhibits strong preference for QDNA over dsDNA, resulting in increased stability of the QDNA motif. A synchrotron radiation circular dichroism melt spectrum is included to convey the increased spectral complexity these motifs possess. More information can be found in the Full Paper by R. Vilar, J. Aldrich‐Wright, et al. on page 2317 ff.