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Inside Back Cover: A Fluorination/Aryl Migration/Cyclization Cascade for the Metal‐Free Synthesis of Fluoro‐Benzoxazepines (Chem. Eur. J. 11/2016)
Author(s) -
Ulmer Anna,
Brunner Christoph,
Arnold Andreas M.,
Pöthig Alexander,
Gulder Tanja
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600133
Subject(s) - reagent , cascade , chemistry , aryl , combinatorial chemistry , amide , molecule , cover (algebra) , stereochemistry , organic chemistry , engineering , alkyl , chromatography , mechanical engineering
The search for efficient fluorination methods , which ideally help to unlock new reactivities, is fueled by the importance of fluorinated molecules. With the bench‐stable F‐benziodoxole a new reagent has been established that reveals unexpected fluorination chemistry. Exemplified by the treatment of o ‐amide styrenes with the iodane, a new class of F‐benzoxazepines became available furnished by a fluorination/migration/cyclization cascade. The chemoselective generation of these F‐heterocycles is in clear contrast to the products obtained with the common F‐reagents. More information can be found in the Communication by T. Gulder et al. page 3660 ff.