Rhodium‐ and Iridium‐Catalyzed Asymmetric Addition of Optically Pure  P ‐Chiral  H ‐Phosphinates to Aldehydes Leading to Optically Active α‐Hydroxyphosphinates | Zendy

Li Qiang | Zendy; Chen Tieqiao | Zendy; Xu Qing | Zendy; Han LiBiao | Zendy

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Rhodium‐ and Iridium‐Catalyzed Asymmetric Addition of Optically Pure P ‐Chiral H ‐Phosphinates to Aldehydes Leading to Optically Active α‐Hydroxyphosphinates

Author(s) -

Li Qiang,

Chen Tieqiao,

Xu Qing,

Han LiBiao

Publication year - 2016

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201600115

Subject(s) - iridium , optically active , rhodium , catalysis , enantioselective synthesis , chemistry , combinatorial chemistry , organic chemistry

Optically active α ‐ hydroxyphosphinates with both C ‐ and P ‐stereogenic centers are obtained by rhodium‐ or iridium‐catalyzed substrate‐directed stereoselective addition of the optically pure H‐ phosphinates to aldehydes. The reaction most probably proceeds by a transition‐metal‐catalyzed mechanism with hydridometal complexes as key intermediates in the catalytic cycle.

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