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Rhodium‐ and Iridium‐Catalyzed Asymmetric Addition of Optically Pure P ‐Chiral H ‐Phosphinates to Aldehydes Leading to Optically Active α‐Hydroxyphosphinates
Author(s) -
Li Qiang,
Chen Tieqiao,
Xu Qing,
Han LiBiao
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201600115
Subject(s) - iridium , optically active , rhodium , catalysis , enantioselective synthesis , chemistry , combinatorial chemistry , organic chemistry
Optically active α ‐ hydroxyphosphinates with both C ‐ and P ‐stereogenic centers are obtained by rhodium‐ or iridium‐catalyzed substrate‐directed stereoselective addition of the optically pure H‐ phosphinates to aldehydes. The reaction most probably proceeds by a transition‐metal‐catalyzed mechanism with hydridometal complexes as key intermediates in the catalytic cycle.