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Inside Back Cover: Cross‐Aldol Reaction of Isatin with Acetone Catalyzed by Leucinol: A Mechanistic Investigation (Chem. Eur. J. 34/2015)
Author(s) -
Kabeshov Mikhail A.,
Kysilka Ondřej,
Rulíšek Lubomír,
Suleimanov Yury V.,
Bella Marco,
Malkov Andrei V.,
Kočovský Pavel
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201590155
Subject(s) - isatin , aldol reaction , catalysis , aldol condensation , enamine , acetone , chemistry , substrate (aquarium) , polymer chemistry , organic chemistry , oceanography , geology
A catalyst's catalyst Investigation of the leucinol‐catalyzed aldol reaction of isatin with acetone revealed an intriguing and unusual mechanistic concept: apart from being a substrate, isatin also acts as a dichotomous co‐catalyst that accelerates the turnover‐limiting step: the formation of the reactive syn ‐enamine. This concept resembles that of a wind turbine: only when the wind is blowing, that is, when the starting material is present, rotation commences and gives rise to the desired product. For more details, see the Full Paper by M. A. Kabeshov, A. V. Malkov, P. Kočovský, and co‐workers on page 12026 ff.