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Cover Picture: A Versatile Approach to CF 3 ‐Containing 2‐Pyrrolidones by Tandem Michael Addition–Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors (Chem. Eur. J. 33/2015)
Author(s) -
Mateu Natalia,
Ciordia Myriam,
Delgado Oscar,
SánchezRoselló María,
Trabanco Andrés A.,
Van Gool Michiel,
Tresadern Gary,
PérezBenito Laura,
Fustero Santos
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201590147
Subject(s) - docking (animal) , protein data bank (rcsb pdb) , chemistry , rna , stereochemistry , biochemistry , medicine , nursing , gene
The cover picture shows the docking of one of the β‐secretase 1 (BACE1) inhibitors designed and synthesized in this study in complex with the crystal structure of the enzyme (PDB ID: 3ZOV). This appears encapsulated in a sketch of the human brain, and the molecular structure of the inhibitors is shown in the circle. For the comprehensive study, see the Full Paper by N. Mateu, O. Delgado, S. Fustero, and colleagues on page 11719 ff.