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Back Cover: Direct Synthesis of Chiral 3‐Arylsuccinimides by Rhodium‐Catalyzed Enantioselective Conjugate Addition of Arylboronic Acids to Maleimides (Chem. Eur. J. 31/2015)
Author(s) -
Gopula Balraj,
Yang ShuHan,
Kuo TingShen,
Hsieh JenChieh,
Wu PingYu,
Henschke Julian P.,
Wu HsyuehLiang
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201590141
Subject(s) - enantioselective synthesis , chemistry , succinimide , conjugate , pyrrolidine , rhodium , catalysis , nucleophile , diene , optically active , combinatorial chemistry , organic chemistry , mathematical analysis , natural rubber , mathematics
Optically active 3‐substituted succinimide and pyrrolidine moieties can be found in biologically active molecules, making their synthetic accessibility of relevance to both discovery and development chemists. In their Full Paper on page 11050 ff. , J.‐C. Hsieh, J. P. Henschke, H.‐L. Wu, et al. describe chiral Rh I catalysts comprising diaryl bicyclo[2.2.1]diene ligands that were utilized in the enantioselective arylation of N ‐substituted maleimides by using arylboronic acids as nucleophilic donors. The protocol is convenient and water tolerant while offering access to a variety of 3‐arylsuccinimides in a highly enantioselective manner under relatively mild reaction conditions.