Inside Back Cover: Photoregulation of α‐Chymotrypsin Activity by Spiropyran‐Based Inhibitors in Solution and Attached to an Optical Fiber (Chem. Eur. J. 30/2015)

A new class of spiropyran‐based protease inhibitor is reported that reversibly photoswitches between an active spiropyran (SP) isomer and a less active merocyanine (MC) isomer on irradiation with UV and visible light, respectively. Switching occurs in solution and also when attached to the surface of a microstructured optical fiber (MOF). The center of the image shows a space‐filling model of the target protease, α‐chymotrypsin and a MOF is depicted in the upper‐right‐hand corner. SP and MC isomers of representative inhibitors are also illustrated. More details of this research can be found in the Full Paper by A. D. Abell and co‐workers on page 10703 ff.