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Cover Picture: Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases (Chem. Eur. J. 29/2015)
Author(s) -
Touisni Nadia,
Kanfar Nasreddine,
Ulrich Sébastien,
Dumy Pascal,
Supuran Claudiu T.,
Mehdi Ahmad,
Winum JeanYves
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201590127
Subject(s) - carbonic anhydrase , chemistry , fluorescence , nanoparticle , cytosol , monomer , gene isoform , inhibitory postsynaptic potential , selectivity , combinatorial chemistry , sulfonamide , biophysics , enzyme , potency , ic50 , biochemistry , stereochemistry , nanotechnology , in vitro , organic chemistry , catalysis , materials science , physics , quantum mechanics , neuroscience , biology , gene , polymer
A multivalency effect against zinc metalloenzyme carbonic anhydrases has been demonstrated with sulfonamide inhibitor‐coated fluorescent silica nanoparticles. In their Communication on page 10306 ff. , J.‐Y. Winum and co‐workers report inhibitory potency improvement as well as isoform‐selectivity modulation towards the monomeric cytosolic isoforms CA I and CA II.