Cover Picture: Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases (Chem. Eur. J. 29/2015) | Zendy

Touisni Nadia | Zendy; Kanfar Nasreddine | Zendy; Ulrich Sébastien | Zendy; Dumy Pascal | Zendy; Supuran Claudiu T. | Zendy; Mehdi Ahmad | Zendy; Winum JeanYves | Zendy

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Cover Picture: Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases (Chem. Eur. J. 29/2015)

Author(s) -

Touisni Nadia,

Kanfar Nasreddine,

Ulrich Sébastien,

Dumy Pascal,

Supuran Claudiu T.,

Mehdi Ahmad,

Winum JeanYves

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201590127

Subject(s) - carbonic anhydrase , chemistry , fluorescence , nanoparticle , cytosol , monomer , gene isoform , inhibitory postsynaptic potential , selectivity , combinatorial chemistry , sulfonamide , biophysics , enzyme , potency , ic50 , biochemistry , stereochemistry , nanotechnology , in vitro , organic chemistry , catalysis , materials science , physics , quantum mechanics , neuroscience , biology , gene , polymer

A multivalency effect against zinc metalloenzyme carbonic anhydrases has been demonstrated with sulfonamide inhibitor‐coated fluorescent silica nanoparticles. In their Communication on page 10306 ff. , J.‐Y. Winum and co‐workers report inhibitory potency improvement as well as isoform‐selectivity modulation towards the monomeric cytosolic isoforms CA I and CA II.

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