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Cover Picture: Stereoselective Peterson Olefinations from Bench‐Stable Reagents and N ‐Phenyl Imines (Chem. Eur. J. 24/2015)
Author(s) -
Das Manas,
Manvar Atul,
Jacolot Maïwenn,
Blangetti Marco,
Jones Roderick C.,
O'Shea Donal F.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201590102
Subject(s) - geminal , facade , chemistry , imine , stereoselectivity , reagent , silane , organic chemistry , combinatorial chemistry , catalysis , engineering , structural engineering
Peterson olefination as represented by the building facade is one of the historic yet still essential building blocks of synthetic chemistry. In their Communication on page 8737 ff. , D. O'Shea et al. report on the first stereoselective aza‐Peterson reaction utilising bench stable geminal bis‐silane reagents with imine substrates. These advances have allowed several long‐standing limitations for this double bond forming reaction to be overcome. The facade itself is the entrance into the original building of the Royal College of Surgeons in Ireland which has housed the chemistry department since its foundation in 1828.