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Cover Picture: Sulfoxide‐Directed Metal‐Free ortho ‐Propargylation of Aromatics and Heteroaromatics (Chem. Eur. J. 20/2015)
Author(s) -
Eberhart Andrew J.,
Shrives Harry J.,
Álvarez Estela,
Carrër Amandine,
Zhang Yuntong,
Procter David J.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201590082
Subject(s) - intramolecular force , chemistry , nucleophile , sulfoxide , intermolecular force , carbene , combinatorial chemistry , stereochemistry , organic chemistry , molecule , catalysis
Taking signage from the University of Manchester campus, the image illustrates a new, metal‐free direction for cross‐coupling technology. The sulfoxide‐directed, metal‐free ortho ‐propargylation of aromatics exploits intermolecular delivery of a nucleophile to sulfur followed by an intramolecular relay to carbon. The operationally simple cross‐coupling procedure is general and highly selective. The ‘safety‐catch’ nature of the directing group is also illustrated. The background shows the University's Alan Turing Building. For more details, see the Full Paper by D. J. Procter and co‐workers on page 7428 ff.