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Back Cover: Diazo‐ and Transition‐Metal‐Free CH Insertion: A Direct Synthesis of β‐Lactams (Chem. Eur. J. 4/2015)
Author(s) -
Gomes Luis F. R.,
Veiros Luís F.,
Maulide Nuno,
Afonso Carlos A. M.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201590014
Subject(s) - diazo , ylide , insertion reaction , chemistry , metal , decomposition , iodide , transition metal , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
For a long time, diazo derivatives have been used for the generation of metal carbenoids and further CH insertion reactions even though they are toxic and explosive. In their Communication on page 1449 ff., N. Maulide, C. A. M. Afonso, and co‐workers describe the use of a common iodide source to allow the formation of known iodonium ylides. Their in situ decomposition affords the CH‐insertion β‐lactam product. In the picture, Prince Henry holds the crucial, glowing ylide intermediate and leads the brave sailors about to depart in search for uncharted land (monument to the Age of Discoveries in Lisbon, Portugal).