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Cover Picture: Synthesis of a Pentasaccharide and Neoglycoconjugates Related to Fungal α‐(1→3)‐Glucan and Their Use in the Generation of Antibodies to Trace Aspergillus fumigatus Cell Wall (Chem. Eur. J. 3/2015)
Author(s) -
Komarova Bozhena S.,
Orekhova Maria V.,
Tsvetkov Yury E.,
Beau Remi,
Aimanianda Vishukumar,
Latgé JeanPaul,
Nifantiev Nikolay E.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201590005
Subject(s) - aspergillus fumigatus , chemistry , conjugate , pathogen , microbiology and biotechnology , biology , mathematical analysis , mathematics
The synthetic oligosaccharide conjugate representing a fragment of surface α‐(1→3)‐glucan of Aspergillus fumigatus , is depicted on the cover. The conjugate was obtained by a convergent α‐stereoselective scheme and used to generate polyclonal antibodies able to trace this harmful pathogen. This discovery is a first step to the development of a diagnostic test system and a vaccine to detect and fight this life‐threatening pathogen. Details are discussed in the Full Paper by N. E. Nifantiev et al. on p. 1029 ff.