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Inside Cover: Regioselective Synthesis of Polyheterohalogenated Naphthalenes via the Benzannulation of Haloalkynes (Chem. Eur. J. 50/2015)
Author(s) -
Lehnherr Dan,
Alzola Joaquin M.,
Lobkovsky Emil B.,
Dichtel William R.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201585002
Subject(s) - regioselectivity , naphthalene , chemistry , halide , combinatorial chemistry , catalysis , medicinal chemistry , stereochemistry , organic chemistry
Polyheterohalogenated naphthalenes are synthesized by using a copper‐catalyzed regioselective benzannulation of chloro‐, bromo‐, and iodoalkynes. This modular approach based on readily available haloalkynes and benzaldehydes provides independent control of halide substitution at six of the seven naphthalene positions of 2‐arylnaphthalenes. Insight into the reaction mechanism and the origin of the regioselectivity is described by W. R. Dichtel et al. in their Full Paper on page 18122 ff.