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Cover Picture: Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring (Chem. Eur. J. 50/2015)
Author(s) -
Lo Re Daniele,
Zhou Ying,
Mucha Joanna,
Jones Leigh F.,
Leahy Lorraine,
Santocanale Corrado,
Krol Magdalena,
Murphy Paul V.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201585001
Subject(s) - cell migration , in vitro , cell , cell culture , chemistry , small molecule , cell growth , natural product , cancer research , biochemistry , biology , genetics
Tumour cell migration can be stopped by small molecules such as migrastatin, a natural product that inhibits tumour cell migration (μ M range) in vitro. In their Full Paper on page 18109 ff. , P. Murphy et al. describe the synthesis and structure–activity studies of migrastatin and its analogues. Compounds were tested in vitro against both breast and pancreatic cancer cell lines and inhibition of tumour cell migration was observed in both wound‐healing (scratch) and Boyden chamber assays, with one analogue showing low affinity for a range of secondary drug targets, indicating it is at low risk of displaying adverse side effects.