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Cover Picture: Sensing Protein Surfaces with Targeted Fluorescent Receptors (Chem. Eur. J. 45/2015)
Author(s) -
Nissinkorn Yael,
LahavMankovski Naama,
Rabinkov Aharon,
Albeck Shira,
Motiei Leila,
Margulies David
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201584501
Subject(s) - fluorescence , receptor , surface protein , molecular recognition , fluorescent protein , computational biology , molecule , chemistry , biophysics , nanotechnology , green fluorescent protein , biology , materials science , biochemistry , gene , physics , optics , organic chemistry , virology
Protein surface recognition by synthetic receptors is a challenging goal in the analytical biosciences owing to the immense complexity of the biological targets. In their Full Paper on page 15981 ff. , D. Margulies et al. describe the development of a method for tracking changes that occur on the surfaces of specific proteins with fluorescent molecular probes. The authors demonstrate how such systems could be used to detect surface modifications of genetically labelled proteins, which results from the binding to metal ions, small molecules, and protein partners.