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Inside Back Cover: Spectroscopic and Kinetic Evidence for the Crucial Role of Compound 0 in the P450 cam ‐Catalyzed Hydroxylation of Camphor by Hydrogen Peroxide (Chem. Eur. J. 43/2015)
Author(s) -
Franke Alicja,
van Eldik Rudi
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201584303
Subject(s) - hydrogen peroxide , chemistry , hydroxylation , substrate (aquarium) , catalysis , camphor , cover (algebra) , photochemistry , peroxide , stereochemistry , medicinal chemistry , enzyme , organic chemistry , mechanical engineering , oceanography , engineering , geology
The hydroperoxo iron(III) intermediate P450 cam Fe III OOH (Cpd 0) was transiently observed in the peroxoshunt oxidation of the substrate‐free enzyme by hydrogen peroxide under mild basic conditions and low temperature. Kinetic data provide, for the first time, direct evidence for the catalytic activity of the P450 cam Fe III OOH intermediate in the oxidation of the natural substrate of cytochrome P450 cam . Notably, no spectroscopic evidence for the formation of Cpd I or Cpd II could be observed. For more details, please see the Full Paper by A. Franke and R. van Eldik on page 15201 ff.