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Frontispiece: New Dual Fluorescent Probe for Simultaneous Biothiol and Phosphate Bioimaging
Author(s) -
Resa Sandra,
Orte Angel,
Miguel Delia,
Paredes Jose M.,
PuenteMuñoz Virginia,
Salto Rafael,
Giron Maria D.,
RuedasRama Maria J.,
Cuerva Juan M.,
AlvarezPez Jose M.,
Crovetto Luis
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201584262
Subject(s) - chemistry , fluorescence , moiety , thiolysis , phosphate , xanthene , derivative (finance) , combinatorial chemistry , biochemistry , stereochemistry , photochemistry , antioxidant , physics , polyphenol , proanthocyanidin , quantum mechanics , financial economics , economics
Bioimaging The combined action of inorganic phosphate and glutathione has a clear biological relevance, that is, in cancer, obesity, diabetes, and hypoxia. A new sulfinyl xanthene derivative (DNBS‐GG; DNBS=2,4‐dinitrobenzenesulfinate, GG=Granada Green) that can act as a simultaneous dual sensor of biological biothiols and phosphate anions was designed, synthesized, and used in cells. Its sensing mechanism implies thiolysis of the sulfinyl group of the weakly fluorescent DNBS‐GG by biological thiols at physiological pH, releasing the fluorescent GG moiety that simultaneously responds to phosphate anions through its fluorescence decay time. For more details see the Full paper by J. M. Cuerva, L. Crovetto et al. on page 14772 ff.