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Cover Picture: A Modular Synthesis of Conformationally Preorganised Extended β‐Strand Peptidomimetics (Chem. Eur. J. 42/2015)
Author(s) -
Yamashita Tohru,
Knipe Peter C.,
Busschaert Nathalie,
Thompson Sam,
Hamilton Andrew D.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201584201
Subject(s) - peptidomimetic , modular design , cover (algebra) , molecular mimicry , chemistry , stereochemistry , mimicry , combinatorial chemistry , computer science , biochemistry , peptide , biology , engineering , genetics , antibody , mechanical engineering , operating system , ecology
In the fight against disease . new molecular scaffolds are required to mediate protein–protein interactions. A promising strategy for the recognition of these large and often featureless interfacial surfaces is the mimicry of secondary structural protein elements. In their Communication on page 14699 ff. , S. Thompson, A. D. Hamilton and co‐workers detail a modular and scalable synthesis of non‐peptidic mimics that are conformationally preorganised by dipolar repulsion to reproduce the presentation of amino acid side‐chains from one face of a β–strand.