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Inside Back Cover: Strain‐Promoted Reaction of 1,2,4‐Triazines with Bicyclononynes (Chem. Eur. J. 41/2015)
Author(s) -
Horner Katherine A.,
Valette Nathalie M.,
Webb Michael E.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201584103
Subject(s) - cover (algebra) , strain (injury) , chemistry , range (aeronautics) , reaction rate , computational chemistry , crystallography , polymer chemistry , materials science , organic chemistry , composite material , catalysis , engineering , biology , mechanical engineering , anatomy
A new (very slow) entrant in the bio‐orthogonal reaction race 1,2,4,5‐Tetrazines react rapidly with a wide range of strained dienophiles; however, the corresponding reactions of 1,2,4‐triazines have not all been evaluated. In their Full Paper on page 14376 ff. , M. E. Webb et al. report the synthesis of 1,2,4‐triazinylalanine and show that while it does react with bicyclononynes (but not norbonenes), the reaction rate is orders of magnitude slower than that for the corresponding tetrazines.