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Frontispiece: Gd‐DTPA‐Dopamine‐Bisphytanyl Amphiphile: Synthesis, Characterisation and Relaxation Parameters of the Nanoassemblies and Their Potential as MRI Contrast Agents
Author(s) -
Gupta Abhishek,
Willis Scott A.,
Waddington Lynne J.,
StaitGardner Tim,
de Campo Liliana,
Hwang Dennis W.,
Kirby Nigel,
Price William S.,
Moghaddam Minoo J.
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201584062
Subject(s) - amphiphile , lyotropic , paramagnetism , relaxation (psychology) , synchrotron , mri contrast agent , transmission electron microscopy , materials science , nuclear magnetic resonance , liposome , dynamic light scattering , chemistry , chemical physics , nanotechnology , nanoparticle , copolymer , organic chemistry , optics , condensed matter physics , physics , polymer , psychology , social psychology , liquid crystalline
Paramagnetic Amphiphile . A new paramagnetic amphiphile, Gd‐DTPA‐Dopamine‐Bisphytanyl, which is readily capable of self‐assembling into liposomal nanoassemblies upon dispersion in an aqueous solution, is reported. The neat amphiphile, its lyotropic bulk phases and its dispersed nanoassemblies were characterised using a variety of techniques such as polarised optical microscopy, synchrotron small angle X‐ray scattering and cryogenic transmission electron microscopy. To assess the potential of these paramagnetic liposomal nanoassemblies as MRI contrast agents, their in vitro relaxivities were measured at low and high magnetic field strengths. For more details, see the Full Paper by M. J. Moghaddam, W. S. Price, et al. on page 13950 ff.